Academy
Targeting the pathway of GSK-3β/nerve growth factor to attenuate post-infarction arrhythmias by preconditioned adipose-derived stem cells (2017)
In this study, it showed that BP-primed human adipose-derived stem cells (BP-pretreated hADSCs) significantly reduced arrhythmias following myocardial infarction and enhanced the cells’ cardioprotective effects via the PI3K/Akt/GSK-3β pathway. Compared with naïve hADSCs, the transplantation of BP-pretreated hADSCs showed significantly improved efficacy in reducing fibrosis and restoring cardiac function.
Lee, T. M., Harn, H. J., Chiou, T. W., Chuang, M. H., Chen, C. H., Lin, P. C., & Lin, S. Z. (2017). Targeting the pathway of GSK-3β/nerve growth factor to attenuate post-infarction arrhythmias by preconditioned adipose-derived stem cells. Journal of molecular and cellular cardiology, 104, 17–30.
Host pre-conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome (2020)
In this study, it showed that BP can rejuvenate the ageing heart and improve hADSC engraftment by regulating the ROS/NLRP3 inflammasome-mediated cardiac fibrosis after myocardial infarction, significantly reducing ROS levels and NLRP3 inflammasome activity in the hearts of aged rats. BP-treated aged rats showed a 40% reduction in cardiac fibrosis compared to untreated rats, demonstrating its potential to improve stem cell engraftment after myocardial infarction.
Lee T-M, Harn H-J, Chiou T-W, et al. Host pre-conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome. J Cell Mol Med. 2020; 24: 12272–12284.
Preconditioned adipose-derived stem cells ameliorate cardiac fibrosis by regulating macrophage polarization in infarcted rat hearts through the PI3K/STAT3 pathway (2019)
In this study, it showed that BP-pretreated human adipose-derived stem cells (BP-pretreated hADSCs) effectively modified macrophage phenotypes into M2 phenotype (immunomodulation) and reduced myocardial fibrosis via the PI3K/STAT3 pathway, significantly enhanced cardiac function and stem cell engraftment. Compared to naïve ADSCs, BP-pretreated hADSCs markedly increased M2 macrophage infiltration and myocardial IL-10 levels.
Lee, TM., Harn, HJ., Chiou, TW. et al. Preconditioned adipose-derived stem cells ameliorate cardiac fibrosis by regulating macrophage polarization in infarcted rat hearts through the PI3K/STAT3 pathway. Lab Invest 99, 634–647 (2019).