Academy
A One-Step, Monolayer Culture and Chemical-Based Approach to Generate Insulin-Producing Cells From Human Adipose-Derived Stem Cells to Mitigate Hyperglycemia in STZ-Induced Diabetic Rats (2022)
In this study, using an innovative one-step, rapid protocol, human adipose-derived mesenchymal stem cells (hADSCs) were converted into human insulin-producing cells (hIPCs), which the expression of genes associated with pancreatic lineage specification, such as PDX1, ISL1, and INS (encoding insulin), producing insulin and exhibit immune-privileged properties. The results demonstrated that transplantation of hIPCs significantly alleviates hyperglycemia in streptozotocin-induced diabetic rats, offering a promising approach for safe and cost-effective diabetes treatment.
Liang, R. Y., Zhang, K. L., Chuang, M. H., Lin, F. H., Chen, T. C., Lin, J. N., Liang, Y. J., Li, Y. A., Chen, C. H., Wong, P. L. J., Lin, S. Z., & Lin, P. C. (2022). A One-Step, Monolayer Culture and Chemical-Based Approach to Generate Insulin-Producing Cells From Human Adipose-Derived Stem Cells to Mitigate Hyperglycemia in STZ-Induced Diabetic Rats. Cell transplantation, 31, 9636897221106995.