Academy
Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm (2024)
This study showed that the intra-articular administration of GXCPC1®, an allogeneic adipose-derived stem cell, was safe and well-tolerated in subjects with therapeutic alternatives to treat knee osteoarthritis (knee OA) during 1 year follow-up period. According to the results, the net change in pain (95% confidence interval (CI) = −7.773 to −2.561t at 12 weeks compared to baseline) and knee function (95% CI = −24.297 to −10.036t at 12 weeks compared to baseline) was better in subjects receiving high-dose GXCPC1® (4 x 10^7 hADSCs in 3mL).
Chen, C. F., Chen, Y. C., Fu, Y. S., Tsai, S. W., Wu, P. K., Chen, C. M., Chen, W. M., Wu, H. H., Lee, C. H., Chang, C. L., Lin, P. C., Kao, Y. C., Chen, C. H., & Chuang, M. H. (2024). Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm. Cell transplantation, 33, 9636897231221882.
The effect of adipose-derived mesenchymal stem cells and chondrocytes with platelet-rich fibrin releasates augmentation by intra-articular injection on acute osteochondral defects in a rabbit model (2018)
This study demonstrated the combination of adipose-derived mesenchymal stem cells (ADSCs) and platelet-rich fibrin releasates (PRFr) can reduce catilage defects by regenerating hyaline-like cartilage without complication.
Hsu, Y. K., Sheu, S. Y., Wang, C. Y., Chuang, M. H., Chung, P. C., Luo, Y. S., Huang, J. J., Ohashi, F., Akiyoshi, H., & Kuo, T. F. (2018). The effect of adipose-derived mesenchymal stem cells and chondrocytes with platelet-rich fibrin releasates augmentation by intra-articular injection on acute osteochondral defects in a rabbit model. The Knee, 25(6), 1181–1191.
Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation (2022)
In this study, the results demonstrated that exosomes derived from GWOXI’s hADSCs and hWJMSCs, processed via proprietary methods, can induce chondrogenic differentiation in vitro, significantly upregulating type II collagen expression and mitigating adipogenesis.
Tsai, Y. C., Cheng, T. S., Liao, H. J., Chuang, M. H., Chen, H. T., Chen, C. H., Zhang, K. L., Chang, C. H., Lin, P. C., & Huang, C. F. (2022). Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation. Tissue engineering and regenerative medicine, 19(6), 1295–1310.
Enhanced Bone Formation in Osteoporotic Mice by a Novel Transplant Combined with Adipose derived Stem Cells and Platelet-rich Fibrin Releasates (2020)
This study demonstrated the combination of hADSCs and PRFr can significantly enhance bone mass density (BMD) in ovariectomy-induced osteoporotic mice compared to the treatment of ADSCs and PRFr alone, indicating the therapeutic potential combination treatment for the treatment of osteoporosis.
Sheu, S. Y., Hsu, Y. K., Chuang, M. H., Chu, C. M., Lin, P. C., Liao, J. H., Lin, S. Z., & Kuo, T. F. (2020). Enhanced Bone Formation in Osteoporotic Mice by a Novel Transplant Combined with Adipose-derived Stem Cells and Platelet-rich Fibrin Releasates. Cell transplantation, 29, 963689720927398.
Regenerative Potential of Platelet-Rich Fibrin Releasate Combined with Adipose Tissue–Derived Stem Cells in a Rat Sciatic Nerve Injury Model (2020)
This study demonstrated that the combination of human adipose tissue–derived stem cells (hADSCs) and platelet-rich fibrin releasate (PRFr) exerts enhanced therapeutic effects in treating sciatic nerve injury in rats compared to treatment with PRFr or hADSCs alone.
Chuang, M. H., Ho, L. H., Kuo, T. F., Sheu, S. Y., Liu, Y. H., Lin, P. C., Tsai, Y. C., Yang, C. H., Chu, C. M., & Lin, S. Z. (2020). Regenerative Potential of Platelet-Rich Fibrin Releasate Combined with Adipose Tissue-Derived Stem Cells in a Rat Sciatic Nerve Injury Model. Cell transplantation, 29, 963689720919438.